Objective: To understand perceived barriers and facilitators to physical activity (PA) among at-risk African American and Hispanic adolescents and adults in a low-income community. Design: Qualitative research was conducted in 2014-2015 using focus groups and a sociodemographic survey. Setting: Three high schools in South Los Angeles, California. Participants: Eight high school-aged adolescent focus groups (n = 64) and 8 adult focus groups (n = 47). Phenomenon of Interest: Perceived barriers and facilitators to PA among predominantly obese and overweight African American and Hispanic adolescents and adults. Analysis: Groups were audio recorded, transcribed, coded, and analyzed using an inductive approach. Results: Participants reported that PA resources were available on school campuses (eg, sports teams) and in the community (eg sidewalks, local parks, fitness classes). Key barriers to PA were intrapersonal (lack of motivation and time constraints) and environmental (safety concerns), whereas facilitators included interpersonal factors (social support). Participants provided valuable insights, including recommendations to increase noncompetitive programs at schools, develop shared-use agreements, and address safety concerns at local parks and public recreational spaces. Conclusions and Implications: The findings suggest that future efforts to promote PA among at-risk minority groups should address intrapersonal and social environmental factors. Community-based programmatic and policy recommendations are provided.